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The SkyScan 1076 is a high-resolution low-dose X-ray micro-CT scanner for
in-vivo studies of small laboratory animals (rats, mice, etc.). This system
has the unique ability to provide non-invasive reconstructed cross-sectional
images with a spatial resolution of up to 9 microns at any point within
the animal. Full 3D models can be constructed and the morphology analysed.
SPECIFICATIONS:
| SYSTEM:
|
SkyScan
1076 In-vivo scanner
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| Maximum
object size |
68mm
or 35mm diameter, 200mm length
|
| X-ray
source |
20-100kV,
10W, <5um spot size (@4W), >10000h expected lifetime, air cooled sealed
type, 4-position automatic filter changer for energy selection
|
| X-ray
detector |
10
Megapixel (4000x2300x12bit) cooled digital X-ray camera with fibre-optic
coupling to scintillator
|
| Reconstruction
arrays |
1000x1000
to 8000x8000 cross-section format (isotropic grid), 9µm / 18µm
/ 35µm pixel size in any place of the scanning area.
|
| Detail
detectability |
9-14
µm (contrast dependent)
|
| Scanning
system |
Source-detector
pair rotation with 0.02 deg. min. step size, 50µm object positioning
accuracy with 400mm travel, 50mm camera positioning/alignment with 1µm
accuracy, <10 microns overall stability during scanning
|
| Host
computer |
Dual Intel Xeon 3.6 GHz, 2GB RAM, 320GB HDD (2x160GB),
internal dual-layer DVD-rewriter, 20.1" LCD monitor 1600x1200pixels,
128MB graphical card with 3D-accelerator, PCI Digital Frame
Grabber, integrated Gigabit (10/100/1000) network and sound,
MS-Mouse with wheel, Microsoft Windows-XP Professional
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| Software
package |
Source
and camera control, preview (35x200mm scan), acquisition for reconstruction,
volumetric (cone-beam) reconstruction of one / several / all cross sections,
ROI-reconstruction, local density measurements in HU, 3D-rendering,
virtual manipulation with reconstructed object, morphology analysis
in 2D and 3D
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| Reconstruction
time |
420ms per cross section (4PC cluster) or 1.1 sec
per cross section (single PC) - 1Kx1K pixels (0.7 deg./step)
|
| Reconstruction
algorithm |
Modified
Feldkamp: multislice volumetric (cone-beam) reconstruction. Up to 2000
slices can be reconstructed after one scan. Full image mode, partial
reconstruction mode, possibility for detailed local reconstruction with
object larger than field of view.
|
| Radiation
safety |
<1µSv/h
average during full scan at 20cm from the instrument surface
|
| Installation
requirements |
Power
100-130V/5A/50-60Hz or 200-240V/3A/50-60Hz, 18-25C temperature, <85%
humidity, vibrations 0.1 to 100Hz <40 microns
|
| Size/Weight |
Desk
top instrument 1500 x 800 x 780mm / 198Kg + computer, monitor, keyboard,
mouse and printer
|
| Animal
holders |
Carbon
composite object bed 65mm diameter / 400mm length (rats), Carbon composite
object bed 33mm diameter / 400mm length (mice)
|
| X-ray
energy selection |
Continuously
variable x-ray source peak energy (20 to 100kV), automatic filter changer
with 4 positions (no filter, Ti 0.025mm, Al 0.5mm, Al 1.0mm, all filters
>99.9% purity)
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| Physiological
monitoring subsystem |
Miniature
CMOS-camera with white LEDs illumination for real time visual monitoring
of animal during scanning, real-time local body movement detection for
non-contact synchronization of scanning with breathing, also air / gas
flow sensor for breathing synchronization, sensor for animal temperature
measurement, body temperature regulation by heated airflow, ECG-amplifier
with "x-ray invisible" connections to the animal's body, software package
for physiological monitoring (temperature measurement and stabilization,
body movement detection, pulse rate measurement for breathing and heart
activitiy, etc.) and support for scanning synchronization with local
body movements / breathing / heart rate
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